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Preheat the oven to 325 degrees F. Line 2 large baking sheets with parchment paper.
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In a medium saucepan, combine the pumpkin, butter, cinnamon, nutmeg, and orange zest. Mix until melted, combined, and fragrant. Remove from heat and let cool slightly.
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In a large bowl, whisk together the flour, baking powder, baking soda, and salt.
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Once the pumpkin mixture is at room temperature, whisk in the eggs, brown sugar, and vanilla.
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Add the pumpkin mixture to the flour mixture and stir well to combine.
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Mix in the cranberries and white chocolate.
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Spoon about 2 tablespoons worth of dough on to the prepared baking sheets. Space the cookies about 2 inches apart.
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Bake cookies for 14-16 minutes. Let the cookies sit on the hot baking sheet for five minutes before transferring to a wire rack to completely cool.
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Just before serving, dust the cookies with powdered sugar to complete the look.